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- S Club
- S Club 7
- S Club 8
- S Club 8 (s Club Juniors)
- S Club Juniors
- Saafir
- Sacred Reich
- Sacred Rite
- Sacrifice
- Sacrilege
- Sadaharu
- Sade
- Safety In Numbers
- Safetysuit
- Saga
- Sage Francis
- Sahara Hotnights
- Saint
- Saint Etienne
- Saint Vitus
- Salad
- Salem
- Saling Ket
- Saliva
- Salt 'n' Pepa
- Salt N Pepa
- Sam Adams
- Sam Nicosia
- Sam Phillips
- Sam Roberts
- Samael
- Samantha Cole
- Samantha Fox
- Samantha Mumba
- Same Difference
- Samhain
- Samiam
- Sammath
- Sammie
- Sammy Hagar
- Sammy Hagar & The Waboritas
- Sammy Kershaw
- Samson
- Sanatorium
- Sanctifica
- Sanctity
- Sanctus Real
- Sandi Thom
- Sandra
- Sandy Denny
- Santana
- Santogold
- Saosin
- Sara Bareilles
- Sara Evans
- Sara Groves
- Sarah Brendel
- Sarah Brightman
- Sarah Buxton
- Sarah Connor